Resources - STEMMCHEQ

Resources

Stay informed and empowered. Here you will find general information about STEM programs and/or Cancer including reports.

General Information

Here you will find general information about STEM programs and/or Cancer including reports.

American Association for Cancer Research (AACR). Cancer Disparities Progress Report 2024.

American Cancer Society. Cancer Facts & Figures 2024. Atlanta: American Cancer Society; 2024

Medical Dictionary

We have created a medical dictionary to help with understanding of medical terminology.

General Health Infographics

These infographics are designed to help break down medical information and from the lens of diverse and underserved populations to increase general health literacy. If patients are unable to understand basic medical information, then understanding cancer(s) will present another hurdle.

Cancer Infographics

These infographics are designed to provide general information on cancer and disparities in each cancer that may impact one or more diverse or unsupported population.

Comprehensive Cancer Portals

These portals will have two access points. One is for patients, caregivers, survivors, and the general public. The other access point is for clinicians, researchers, public health, and other entities. They will go through each cancer from the lens of underserved populations to help them specifically navigate their cancer and they provide information to help those conducting research or seeing patients better understand how to work with diverse populations.

Health Equity Ratings

This system is our foundational work to develop an evaluation system for nonprofit organizations that will assess what they are doing for diverse, underserved, or marginalized populations. The goal is to highlight great work that organizations are doing for communities and to help patients decide which organizations may best help provide them support and community. As they are completed, organizations will be listed by cancer, the group they serve, and the overall rating.

SCHEQ Posters

Posters Presented at Meetings/Conferences

2^nd Health Equity in Clinical Trials Congress

Lack of racial and ethnic diversity in lung cancer cell lines contributes to lung cancer health disparities. Manley E Jr., Leon C, Neely AM, Castillo J, Ramos Correa M, Velarde DA, Yang M, Puente PE, Romero DI, Ren B, Chai W, Gladstone M, Lamango NS, Huang Y, and Offringa, IA.2^nd Health Equity in Clinical Trials Congress. May 8-9, 2024. Atlanta, GA.

Description: This poster is from the paper that we co-authored with the CaRE2 team at University of Southern California – Norris Comprehensive Cancer Center, Florida A & M University, and the university of Florida. In this work, we set out to identify the racial and ethnic diversity of lung cancer cell lines. As cell lines are often used to develop therapeutic targets and are based on currently established databases, we asked how many cell lines were available and their composition. We found that in more than 800 cell lines, 200 were from White, 390 from Asian, 30 from Black/African American, and 0 were from American Indian/Alaskan Native (AI/AN), Hispanic/Latino (H/L), or Native Hawaiian or Other Pacific Islander (NHOPI) individuals, respectively. We also found that 3 alveolar epithelial cell lines were from White individuals, and we had no information on the origin of the bronchiolar epithelial cell lines. There were also 2x more cell lines from male than female patients, and 7x times more cell lines from male than female patients in the Asian subset. This work demonstrates that we have a significant lack of racial, ethnic, and gender diversity in lung cancer cell lines, and this is exacerbating the disparities that we see in clinical trials. View Poster

American Association for Cancer Research Annual Meeting 2024

SCHEQ Foundation (STEMM & Cancer Health Equity): Increasing STEMM diversity and outcomes for patients navigating cancer. Manley E, Jr. AACR Annual Meeting Apr 5-10, 2024. San Diego.

Description: This is the first poster of the SCHEQ Foundation and it was presented at the AACR Annual Meeting. In this poster we highlight some of the structural and systemic issues that we are trying to tackle and why they are important. We show that we are working broadly to increase STEMM access and exposure, increase STEMM workforce diversity, and provide information and resources to help underserved populations understand basic medical information as well as cancer information. We ultimately want to empower scholars and patients to advocate for what they are entitled to, as opposed to what they are told. View Poster

Publications

Peer-Reviewed Publications

Lack of racial and ethnic diversity in lung cancer cell lines contributes to lung cancer health disparities. Leon C, Manley E Jr.,Neely AM, Castillo J, Ramos Correa M, Velarde DA, Yang M, Puente PE, Romero DI, Ren B, Chai W, Gladstone M, Lamango NS, Huang Y, and Offringa, IA. Front Oncol. Nov 1, 2023. 13:1187585.

DOI: https://doi.org/10.3389/fonc.2203.1187585

Factors leading to disparity in lung cancer diagnosis among Black/African American communities in the United States: a qualitative study. Thuo N, Martins T, Manley E Jr., Standifer M, Sultan DH, Faris N, Hill A, Thompson MJ, Jeremiah RD, and Al Achkar M. BMJ Open. Oct 29, 2023. 13(10):e073886

DOI: https://doi.org/10.1136/bmjopen-2023-073886

Correction to: A qualitative study of interactions with oncologists among patients with advanced lung cancer. Al Achkar M,Basu Roy U, Manley E Jr., Standifer M, Baik C, and Walsh, CA. Support Care Cancer. Aug 24, 2023. 31(9):534.

DOI: https://doi.org/10.1007/s00520-023-07995-x

A qualitative study of interactions with oncologists among patients with advanced lung cancer. Al Achkar M, Basu Roy U, Manley E Jr., Standifer M, Baik C, and Walsh, CA. Support Care Cancer. Nov 2022. 30(11):9049-9055

DOI: https://doi.org/10.1007/s00520-022-07309-7

Impact of the Coronavirus Disease 2019 Pandemic on Global Lung Cancer Clinical Trials: Why it matters to people with lung cancer. Basu Roy U, Baird AM, Ciupek A, Fox J, Manley E Jr., Norris K, Scagliotti GV, Wakelee HA, Mitsudomi T, Clark RC, Arndt R, Hirsch FR, Bunn PA, and Smeltzer MP. JTO Clin Res Rep. Feb 2022. 3(2):100269.

DOI: https://doi.org/10.1016/j.jtocrr.2021.100269

TSP1 and TSP2 deficiencies affect LOX protein distribution in the femoral diaphysis and pro-peptide removal in marrow-derived mesenchymal stem cell in vitro. Shearer D, Mervis M, Manley E Jr., Reddy, A, and Alford AI. Connect Tissue Res. Sept 2019. 60(5): 495-506.

DOI: https://doi.org/10.1080/03008207.2019.1593391

Canalization leads to similar whole bone mechanical function at maturity in two inbred strains of mice. Schlecht SH, Smith LM,Ramcharan MA, Bigelow EM, Nolan BT, Mathis NJ, Cathey A, Manley E Jr., Menon R, McEachin RC, Nadeau JH, and Jepsen KJ. J Bone Miner Res. May 1, 2017. 32 (5)1002-1013.

DOI: https://doi.org/10.1002/jbmr.3093

Thrombospondin-2 deficiency alters bone collagen ultrastructure and leads to a brittle bone phenotype. Manley E Jr., Perosky JE, Khoury B, Reddy AB, Kozloff, K, and Alford, AI. J Appl Physiol (1985). Oct 15, 2015. 119(8): 872-81.

DOI: https://doi.org//10.1152/japplphysiol.00340.2015

H460 non-small cell lung cancer stem-like cells yield tumors with increased vascularity . Manley E Jr. and Waxman, DJ. Canc Lett. Apr 28, 2014. 346(1): 63-73.

DOI: https://doi.org/10.1016/j.canlet.2013.12.012

Impact of tumor blood flow modulation on sensitivity of gliosarcoma xenografts to the bioreductive drug banoxantrone. Manley E Jr. and Waxman, DJ. J Pharmacol Exp Ther. Feb 2013. 344(2): 368-77.

DOI: https://doi.org/10.1124/jpet.112.200089

Required test duration for group comparisons in ligament viscoelasticity: a statistical approach. Manley E Jr., Provenzano PP,Heisey D, Lakes R, and Vanderby R Jr. Biorheology. Jan 9, 2003. 40(4): 441-50.